One curiosity (click on the image to see the source):

Kris Gunnars, the author of the reply, wrote the text below this line in his site (click on the text to see the source):

And this is what the authors of the first article Gunnars linked concluded:

In summary, our data suggest that the insulin receptor signalling pathway interferes with leptin signalling […], indicating that hyperinsulinaemia contributes to the pathogenesis of leptin resistance.