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One curiosity (click on the image to see the source):
Kris Gunnars, the author of the reply, wrote the text below this line in his site (click on the text to see the source):
And this is what the authors of the first article Gunnars linked concluded:
In summary, our data suggest that the insulin receptor signalling pathway interferes with leptin signalling […], indicating that hyperinsulinaemia contributes to the pathogenesis of leptin resistance.